Mounting evidence shows nutritional ketosis could revolutionise metabolic health, expert reveals

Keto pioneer presents comprehensive research at international health summit

A compelling case for nutritional ketosis as a powerful intervention for metabolic health and disease reversal was presented at the HOLOLIFE Summit 2025 Europe in Tallinn this weekend. Dorian Greenow, founder of Keto-Mojo and a prominent figure in ketogenic health research, delivered a comprehensive overview of the scientific evidence supporting ketosis in his talk titled "Nutritional Ketosis - The Mountain of Evidence."

An evolutionary approach to metabolism

Greenow began by framing nutritional ketosis not as a fad diet but as humanity's evolutionary default metabolic state. "For most of human history, our bodies regularly entered ketosis between meals and during seasonal food scarcity," Greenow explained to the audience of health professionals and researchers. "Our modern, carbohydrate-rich diet has disrupted this natural metabolic flexibility."

The presentation detailed how ketosis provides the body with dual fuel sources – glucose and ketones – leading to more stable blood sugar levels and reduced insulin requirements. This metabolic state, according to the growing body of research Greenow presented, creates cascading benefits throughout the body's systems.

Clinical evidence for disease reversal

Perhaps most striking were the clinical outcomes Greenow shared from recent trials. Multiple studies have now demonstrated significant reversal of type 2 diabetes through ketogenic interventions, with patients reducing or eliminating medication while achieving improved biomarkers.

"What we're seeing isn't just management of these conditions – it's genuine reversal," Greenow said. He highlighted research showing how nutritional ketosis influences inflammation pathways, brain health, and longevity markers through epigenetic regulation and enhanced mitochondrial function.

The audience appeared particularly interested in emerging research on "metabolic psychiatry," where ketogenic approaches have shown promise in conditions including epilepsy and bipolar disorder. Greenow referenced several controlled trials showing improvement in neurological symptoms through targeted metabolic interventions.

Challenging conventional dietary wisdom

Greenow didn't shy away from addressing how these findings contrast with decades of conventional dietary advice. He presented data linking hyperinsulinemia from high-carbohydrate diets to various chronic diseases that plague modern society.

"The standard nutritional advice to consume 55-60% of calories from carbohydrates simply doesn't align with our evolutionary biology or the clinical evidence," he argued. "We've been running a population-wide experiment with high-carb diets for decades, and the results – rising rates of obesity, diabetes, and metabolic syndrome – speak for themselves."

Empowering patients through metabolic health

Looking to the future, Greenow emphasized the potential for ketogenic approaches to shift healthcare toward prevention rather than management of chronic disease. His own company's development of affordable ketone monitoring technology aims to democratize access to these health insights.

"When patients can see in real-time how dietary choices affect their metabolism, it transforms their relationship with food and health," Greenow noted. He shared case studies of individuals who reversed metabolic conditions through monitored ketogenic interventions.

The three-day HOLOLIFE Summit, running from June 13th to 15th, has brought together leading researchers and clinicians exploring innovative approaches to health optimization. Greenow's presentation, with its focus on the scientific foundation of ketosis rather than sensationalist claims, provided what many attendees described as a highlight of the conference.

As healthcare systems worldwide struggle with rising chronic disease burdens, Greenow's evidence-based approach to nutritional ketosis offers a potentially transformative path forward – one that returns human metabolism to its evolutionary roots while leveraging modern science to optimize health outcomes.

Frequently asked questions

Is ketosis a diet or a default metabolic state?

Dorian Greenow, founder of Keto-Mojo, framed nutritional ketosis as humanity's evolutionary default rather than a fad diet. For most of human history bodies regularly entered ketosis between meals and during seasonal food scarcity, and he argued modern carbohydrate-rich diets disrupted that flexibility.

What clinical outcomes did he present?

Greenow pointed to multiple studies showing significant reversal of type 2 diabetes through ketogenic intervention, with patients reducing or eliminating medication while improving biomarkers. His claim was that this amounts to genuine reversal rather than management of the condition.

How does this conflict with dietary guidelines?

Greenow argued that the standard advice to take 55-60% of calories from carbohydrates does not align with evolutionary biology or the clinical evidence, and linked hyperinsulinemia from high-carbohydrate diets to the chronic diseases common in modern societies.

About the event

This recap is part of the HOLOLIFE Summit 2025 Europe series, recorded in Tallinn on 14 and 15 June 2025. Read the summary of the whole event or join the next edition, HOLOLIFE Summit 2026 Amsterdam, on 14 and 15 November 2026.