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The Human Upgrade: Biohacking for Longevity & PerformanceJim Kwik joins Host Dave Asprey to reveal how AI is quietly eroding human memory and critical thinking, and shares the framework for using it to sharpen your brain instead.

Huberman LabDr. Masud Husain is a Professor of Neurology & Cognitive Neuroscience at the University of Oxford and a leading expert on the science of motivation, apathy, and neurological diseases. We discuss how dopamine and specific brain circuits shape motivation, including how the brain weighs the trade-off between effort vs reward when deciding what goals to pursue. Dr. Husain also explains practical tools to increase motivation, reduce distractions, and make it easier to start and maintain goal pursuit. We also discuss dementia, Parkinson’s and Alzheimer’s disease, including new insights into cognitive resilience and factors that help protect against age-related cognitive decline. Show notes: https://go.hubermanlab.com/masud-husain-295 Thank you to our sponsors AG1: https://drinkag1.com/huberman David: https://davidprotein.com/huberman BetterHelp: https://betterhelp.com/huberman Eight Sleep: https://eightsleep.com/huberman Function: https://functionhealth.com/huberman Timestamps (00:00:00) Masud Husain (00:02:24) Apathy, Motivation (00:08:07) Rewards, Apathy & Motivation; Dopamine (00:13:20) Sponsors: David & BetterHelp (00:15:44) Types of Apathy; Goal Prioritization: Effort vs Rewards (00:23:26) Motivation, Apathy, Tool: Activation Energy & Overthinking (00:29:24) Tools to Increase Motivation: Incentives, Subdivide Tasks, Planning (00:35:13) Subjective Effort, Mental Framing; Learning & Motivation (00:42:24) Sponsors: AG1 & Eight Sleep (00:44:54) Perseverance, Failure; Finding Your Passion, Depression vs Apathy (00:50:58) Self-Concept, Ambition; Life Satisfaction (00:58:25) Psychedelics, Anhedonia & Changing Self (01:03:09) Personal & Social Identity, Tools: Curiosity, Purpose & Dementia Risk (01:11:58) Addiction, Dopamine; Social Media & Dopamine "Hits"? (01:18:36) Sponsor: Function (01:20:13) Dopamine, Parkinson's Disease; Other Roles of Dopamine (01:26:59) Life Purpose, Culture; Reflection, Weighing Decisions (01:34:21) Internal & External Attention (01:39:59) Internal Chatter, Distraction; Working Memory, Stimulants, Nicotine (01:48:54) ADHD, Diagnosis; Attention & Motivation (01:54:34) Goal Planning & Perseverance (01:59:44) Alzheimer's Disease, Dementia, Apathy, Tools: Dementia Risk Factors (02:06:55) Neurodegenerative Disease & Emerging Treatments (02:10:59) Can You Train Attention?, Tool: Reduce Distraction (02:15:14) Enrichment, Art (02:17:45) Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

The Peter Attia DriveView the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this "Ask Me Anything" (AMA) episode, Peter takes a deep dive into the liver and its central role in metabolic health. He explains why the liver can serve as a "cana

The Human Upgrade: Biohacking for Longevity & PerformanceDave Asprey explains why declining NAD+ drives aging, fatigue, and cognitive decline, and lays out a diet, fasting, exercise, and supplementation protocol to rebuild it.

Boundless LifeFull show notes: https://bengreenfieldlife.com/504 In this solosode, you'll get the latest research on three questions I keep getting asked. First, seed oils: a brand-new randomized controlled trial put 52 adults on either a low or a typical Western intake of linoleic acid for 12 weeks, and the resu

The Human Upgrade: Biohacking for Longevity & PerformanceDave Asprey sits down with Gurudev Sri Sri Ravi Shankar for a wide-ranging conversation on curiosity, non-dual consciousness, breathwork's power to calm the mind, and using ancient wisdom to address modern problems like violence, disconnection, and fear.

Boundless LifeFull show notes: https://bengreenfieldlife.com/juliepodcast In this episode with Julie Gibson Clark, I'm highlighting a throwback conversation because the gap it exposed has only gotten wider. There's a leaderboard called the Rejuvenation Olympics where people submit a blood test that measures how f

Longevity Optimization with Kayla Barnes-LentzMuscle is not just something you build in the gym. Dr. Gabrielle Lyon has spent her career arguing it's the organ that actually determines how well you age, and almost none of us have been taught to think about it that way. Dr. Gabrielle Lyon, DO, is the founder of Muscle-Centric Medicine and the New York Times bestselling author of Forever Strong. She's spent over two decades studying muscle as the most overlooked organ in medicine. The line that stuck with me most: she believes we're on track to trade an obesity epidemic for a sarcopenia epidemic, and most people won't see it coming until it's already happened. It's the kind of prediction I can't stop turning over, especially knowing how many women are on these medications right now without anyone telling them how to protect their muscles while they're on them. Join the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women. https://kayla-barnes-lentz.circle.so/checkout/become-a-member This conversation explores: Why muscle, not weight, decides how you age Why most women are not eating enough protein The protein habit most people get backwards Why menopause doesn't have to mean muscle loss What GLP1 users need to know to protect muscle Connect with Kayla: Instagram: https://www.instagram.com/kaylabarnes/ TikTok: https://www.tiktok.com/@femalelongevity Twitter: https://x.com/femalelongevity Website: https://www.kaylabarnes.com/ Spotify: https://open.spotify.com/show/4OLWWn22RGB0argbRPvAaQ?si=8e91b3c9e0ce4054 Apple: https://podcasts.apple.com/us/podcast/longevity-optimization-with-kayla-barnes-lentz/id1591130227 Follow Her Female Protocol: https://www.protocol.kaylabarnes.com Learn more about Dr. Gabrielle Lyon: YouTube: https://www.youtube.com/@DrGabrielleLyon Instagram: https://www.instagram.com/drgabriellelyon/ X: https://x.com/drgabriellelyon Website: https://drgabriellelyon.com/ #longevity #musclecentricmedicine #muscle #proteinintake #strengthtraining #womenslongevity #sarcopenia #menopause #perimenopause #womenshealth #hormonereplacement #longevityoptimization #biohacking #GLP1

The Human Upgrade: Biohacking for Longevity & PerformancePatrick Coles, a physicist and biochemist, makes the case that cancer tumors are the body's intentional toxin-storage vaults rather than random malignant growth, and that lowering your toxic burden, not just fighting the tumor itself, may be the real key to reversing it.

Huberman LabIn this Huberman Lab Essentials episode, my guest Rick Rubin, world-renowned music producer and author of The Creative Act: A Way of Being, and I discuss how to access creativity by noticing ideas, trusting your taste and staying fully present with the work. Rick explains the phases of the creative process and how focus, disengagement, self-doubt, deadlines and meditation can support original work. We also explore perception, pro wrestling and why remaining open to uncertainty can help anyone create more authentically. Thank you to our sponsors AG1: https://drinkag1.com/huberman LMNT: https://drinklmnt.com/huberman Timestamps (00:00:00) Rick Rubin & Creativity (00:00:23) Creativity as a Dream or Cloud (00:01:53) Childhood, Openness & Originality (00:03:29) Trust Your Taste; Experiment, Don't Over-Explain (00:05:28) Announcement: Protocols Live Events (00:07:07) Creative Aperture & New Perspectives (00:07:48) External Feedback & Staying True to the Work (00:09:14) Finishing Creative Projects (00:10:35) Focus, Disengagement & the Subconscious (00:13:15) Sponsor: LMNT (00:15:04) Perception, Storytelling & Uncertainty (00:17:38) Pro Wrestling, Playfulness & Reality (00:18:59) Morning Routine & Receptivity (00:19:50) Four Phases of Creative Work; Deadlines (00:24:47) Sponsor: AG1 (00:26:08) Self-Doubt as a Creative Tool (00:27:05) Capturing Real Moments; Authenticity (00:28:10) Routines, Advice & Staying Open (00:29:45) Look for Clues; Belief & Attention (00:32:01) Staying Present in the Work (00:32:44) Meditation: Mantra, Breath & Awareness (00:34:42) Monroe Institute Surgical Support Series Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

The Tim Ferriss ShowThis episode is devoted to one deceptively simple question: How do you stay close to your partner over time through the inevitable exhaustion, misunderstanding, conflict, disappointment, and change?This episode is brought to you by:Eight Sleep Pod Cover 5 with dual-zone temperature control, so each partner sleeps at their perfect temperatureIn this episode: Esther Perel begins with the basics: appreciation, affection, and replacing chronic complaints with clear requests.Brené Brown explains why marriage is never 50/50 and how she and her husband create what Brené calls a “plan of kindness.” Brad Feld describes the monthly “life dinners” that have helped him and his wife review the previous 30 days, talk honestly about the future, and prevent resentments from building upJim Dethmer offers a practical way to distinguish observable facts from the stories we make up about our partners.Sheila Heen explains how humor and genuine curiosity can serve as an interrupt on an argument that is heating up The late Dr. Sue Johnson then walks us through a “Hold Me Tight” conversation—a way of moving beneath anger and defensiveness to the fear, vulnerability, and need for connection underneath.Terry Real then offers a strikingly simple model for repair and introduces the term “normal marital hatred” - as he put it, nobody ever goes up to him and says “What do you mean by that?!”Finally, Diana Chapman describes what it means to let an outdated version of a marriage end so that two people can consciously choose what comes next for their relationship.Timestamps:Intro from Tim: 00:00:00Esther Perel: 00:01:58Brené Brown: 00:08:21Brad Feld: 00:12:02Jim Dethmer: 00:16:51Shelia Heen: 00:23:04Dr. Sue Johnson: 00:29:26Terry Real: 00:40:14Diana Chapman: 00:46:19Short bios:Esther Perel is an internationally renowned psychotherapist, the New York Times bestselling author of Mating in Captivity and The State of Affairs, and the host of the award-winning podcast Where Should We Begin?Brené Brown is the author of six number-one New York Times bestsellers exploring courage, vulnerability, shame, and resilience; a research professor at the University of Houston; and a professor of practice at the University of Texas at Austin.Brad Feld is an early-stage investor and entrepreneur and a co-founder of Foundry Group, Mobius Venture Capital, and Techstars. He writes on entrepreneurship, leadership, mental health, and sustaining a life beyond work.Jim Dethmer is a co-founder of the Conscious Leadership Group and co-author of The 15 Commitments of Conscious Leadership, an influential framework for building candid, responsible, high-trust relationships.Sheila Heen is the deputy director of the Harvard Negotiation Project, founder of Triad Consulting Group, and co-author of the New York Times bestsellers Difficult Conversations and Thanks for the Feedback.Dr. Sue Johnson was the pioneering clinical psychologist who created Emotionally Focused Therapy. She was named Psychologist of the Year by the American Psychological Association and appointed to the Order of Canada for her global impact on psychotherapy.Terry Real is an internationally recognized family therapist, a bestselling author, and the creator of Relational Life Therapy. He has spent more than four decades helping couples restore intimacy and connection.Diana Chapman is co-author of The 15 Commitments of Conscious Leadership, a cofounder of the Conscious Leadership Group, and founder of the Signal Institute, working with leaders on radical honesty, somatic intelligence, and transformation.*For show notes and past guests on The Tim Ferriss Show, please visit tim.blog/podcast.For deals from sponsors of The Tim Ferriss Show, please visit tim.blog/podcast-sponsorsSign up for Tim’s email newsletter (5-Bullet Friday) at tim.blog/friday.For transcripts of episodes, go to tim.blog/transcripts.Discover Tim’s books: tim.blog/books.Follow Tim:Twitter: twitter.com/tferriss Instagram: instagram.com/timferrissYouTube: youtube.com/timferrissFacebook: facebook.com/timferriss LinkedIn: linkedin.com/in/timferriss See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

The Human Upgrade: Biohacking for Longevity & PerformanceDave Asprey and Gabby Reece swap interviews on biohacking, longevity, and mitochondrial health, then pivot into a candid conversation about fame, parenting, surrender, hormones, and finding peace through purposeful pursuit rather than achievement.
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