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For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio , he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization. Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more. This isn’t just self-improvement - it’s human enhancement backed by data. Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life. Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.

Dave Asprey and psychic medical intuitive Julie Ryan explore whether intuitive abilities can be trained, how they may relate to healing and consciousness, and what Julie says happens as people approach death.

Miranda Kerr joins Dave Asprey to explore how simplifying health around clean living, sleep, stress management, meditation, family, and intentional skincare can create a more sustainable approach to wellness.

Dave Asprey shares the five hacks that helped him lose over 100 pounds and feel decades younger, from inventing butter coffee in Tibet to eating more saturated fat, cutting anti-nutrients, intermittent fasting, and prioritizing nutrition over endless gym sessions.

Dave Asprey breaks down new research on vagus nerve stimulation and memory, feline cancer genetics, inherited cognitive ability, mulberries and the microbiome, and how magnesium changes vitamin D metabolism.

The founders of Young Goose explore science-backed, longevity-focused skincare — covering metabolomic skin testing, key ingredients like ergothioneine and ectoin, mitochondrial dysfunction, vampire exosomes, red light therapy stacking, and proteomics — all aimed at targeting the 12 hallmarks of aging rather than just treating surface symptoms.

Fatty Liver, GLP-1s, Alcohol, Hormones, Brain Fog, Weight Gain & Longevity

Dave Asprey outlines six science-backed methods to melt visceral fat—ranging from high-protein eating and HIIT to cold exposure, weightlifting, quality sleep, and stress reduction—arguing that chronic stress is the root cause that must be addressed for lasting fat loss.

A roundup of five health stories — Novo Nordisk's interest in hair loss, nutritional deficiencies in kids on GLP-1s, stomach-brain synchronization and mental health, food preservatives linked to heart disease, and taurine's stress-protective effects in rats — closing with a reminder to audit the hidden downsides of any health intervention you're already doing.

Dr. Robert Waldinger shares findings from the 85-year Harvard Study of Adult Development revealing that the quality of our relationships—not wealth, fame, or power—is the single greatest predictor of health, happiness, and longevity, and offers practical strategies for building "social fitness" at any life stage.

Dave Asprey and Catharine Arnston explore how spirulina and chlorella may support mitochondrial function, cellular energy, detoxification, brain health, and healthy aging.

A mold illness survivor explains how toxic mold in your home and body causes chronic brain fog, fatigue, and inflammation — and lays out a step-by-step plan to identify the source, remediate your environment, and detox what your body has already absorbed.

Dave Asprey sits down with spiritual teacher Teal Swan to explore narcissism, betrayal, extrasensory perception, the nature of ego, divine masculine and feminine energy, and whether humanity can heal its deepest wounds.
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