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The Human Upgrade: Biohacking for Longevity & Performance
For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio , he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization. Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more. This isn’t just self-improvement - it’s human enhancement backed by data. Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life. Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.
Episodes
Episode 15240:14:42The Most Important Longevity Molecule I've Ever Found : 1524
Dave Asprey explains why declining NAD+ drives aging, fatigue, and cognitive decline, and lays out a diet, fasting, exercise, and supplementation protocol to rebuild it.
Episode 15230:35:32The Scientist Monk: Gurudev Sri Sri Ravi Shankar : 1523
Dave Asprey sits down with Gurudev Sri Sri Ravi Shankar for a wide-ranging conversation on curiosity, non-dual consciousness, breathwork's power to calm the mind, and using ancient wisdom to address modern problems like violence, disconnection, and fear.
Episode 15221:03:07The Wild New Theory of Cancer (It's GOOD For You?) : 1522
Patrick Coles, a physicist and biochemist, makes the case that cancer tumors are the body's intentional toxin-storage vaults rather than random malignant growth, and that lowering your toxic burden, not just fighting the tumor itself, may be the real key to reversing it.
Episode 15212:46:40Scream Cream and Weekly Injections (Double Episode) | Gabby Reece : 1521
Dave Asprey and Gabby Reece swap interviews on biohacking, longevity, and mitochondrial health, then pivot into a candid conversation about fame, parenting, surrender, hormones, and finding peace through purposeful pursuit rather than achievement.
Episode 15200:15:10It's Weird, But It Turns On Your Anti-Aging Switch : 1520
Save Up To $600: SUNLIGHTEN.COM/DAVETry TrueDark glasses: https://truedark.comTry Danger Coffee: https://dangercoffee.com/discount/davetubeTry Suppgrade Labs: https://shopsuppgradelabs.com/Most people see chronic fatigue and brain fog as permanent conditions caused by getting older, but this video cuts through that misconception by explaining that these symptoms are actually the direct result of damaged mitochondria piling up inside your cells because a specific longevity switch called mitophagy has been turned off. You'll also learn:Why mitophagy, not aging, controls fatigue and brain fogHow damaged mitochondria pile up when this switch turns offThe early signs your mitophagy switch is underperformingWhat actually flips mitophagy back onTry Danger Creatine: https://dangercoffee.com/products/danger-creatineTry TrueDark glasses: https://truedark.comTry Danger Coffee: https://dangercoffee.com/discount/davetubeTry Suppgrade Labs: https://shopsuppgradelabs.com/Thank you to our sponsors!PredictiveMind™ | Get your Brain Pattern Mapping report at predictivemind.io/dave and use code DAVE for 10% off.Viome | Check it out at viome.com and use code 16DAVE for 16% off. It’s time to stop guessing and start knowing your body.iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVETimestamps:00:00 – The Longevity Switch00:59 – Mitochondria: Power Plants02:14 – What Is Mitophagy04:05 – How Stress Blocks It05:36 – Exercise Extremes07:29 – NAD+ and Silent Damage08:59 – Reversing It: Fasting10:27 – REHIT and Cold Exposure12:02 – The Supplement StackConnect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/Dave Asprey’s BEYOND Conference: https://beyondconference.com/Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15Upgrade Labs: https://upgradelabs.com40 Years of Zen: https://40yearsofzen.com See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
Episode 15190:10:54Depressing Fruit, Vitamin (C)ancer, Sheep Wool, Oral GLP-1s, Endless Exercise, and more : 1519
Dave breaks down an FDA-cleared inhaled Alzheimer's trial, a breakthrough in adult brain self-repair, a wool-derived alternative to collagen for bone regeneration, promising oral GLP-1 weight loss data, why the standard exercise guidelines fall far short of real heart protection, and the newly clarified science behind IV vitamin C's anti-cancer effect, closing with what Linus Pauling's fifty-year vindication teaches about revisiting the ideas you gave up on too soon.
Episode 15180:41:29Dave Solo Pod: The Original Smart Drug Masterclass : 1518
Dave Asprey breaks down piracetam and the racetam family, the original nootropics that launched the smart drug movement, covering how they work, who benefits, proper dosing, and the safety and regulatory landscape around them.
Episode 15171:11:13Steven Greer | UAP’s and Remote Viewing Techniques for Non-Human Life : 1517
Dr. Steven Greer, a retired emergency physician and 35-year UFO researcher, joins Dave Asprey to make the case that extraterrestrial intelligence is already interacting with Earth, that suppressed free-energy technology could end global poverty, and that humanity's future depends on a truthful—not weaponized—disclosure before it's too late.
Episode 15160:13:32300mg Improves Appearance of Wrinkles In 7 Days (Study) : 1516
Skin ages faster when oxidative stress overwhelms your defenses, so this episode explains why glutathione — the body's master antioxidant — protects collagen better than collagen itself, and how a new delivery system (RO-GSH) finally makes topical glutathione work, visibly improving wrinkles and skin tone in just one week.
Episode 15150:10:33Longevity Music, Anti-Aging Nasal Spray, How To Look 20, and more... : 1515
This week's biohacking roundup covers a drug-repurposing screen for longevity, protein restriction's anti-aging effects via FGF21, a new cadaver-derived skin injectable, arts engagement slowing biological aging, and a review of 41 studies testing biohacking interventions (including semaglutide) against epigenetic clocks.
Episode 15141:00:43Here's How You Can Have a 3-hour Orgasm (real!) : 1514
Author Regena "Mama Gina" joins Dave Asprey to reveal how embracing pleasure, embodiment and reverent surrender heals trauma, restores intuition and unlocks the divine feminine in women and men alike.
Episode 15131:12:44I Take 150 Pills a Day (But This One Is My Workhorse) | Resbiotic : 1513
Dr. Vivek Lal, the physician scientist who discovered the gut-lung axis, joins Host Dave Asprey to reveal how your gut bacteria control lung inflammation through the MMP-9 pathway, and why fixing your lung microbiome may be the next frontier in longevity and respiratory health.